Endocrinology and Metabolism

So Young Lee (Lee SY)

4 Articles

Age-dependent Kisspeptin Effects on the GnRH Neurons in Male and Female Mice.: Janardhan P Bhattarai, Seon Ah Park, Hua Yin, Soo Joung Park, Jae Gyu Jeon, Kee Wan Chang, So Young Lee, Pan Dong Ryu, Seong Kyu Han; J Korean Endocr Soc. 2008;23(5):302-309. Published online October 1, 2008; DOI: https://doi.org/10.3803/jkes.2008.23.5.302

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BACKGROUND
The gonadotropin releasing hormone (GnRH) neurons play a pivotal role in the central regulation of fertility. Kisspeptin binds to the G-protein coupled receptor 54 (GPR54) and GPR54 has been shown to be essential for puberty and subsequent fertility in humans. The recent in vivo studies have proved that kisspeptin is an extremely potent activator of GnRH neurons. However, the precise mechanism of action of kisspeptin on the GnRH neurons and the age-dependent kisspeptin effects are not yet fully understood. In this study, we investigated the effects of kisspeptin on the GnRH neurons over the developmental stages in male and female mice. METHODS: Young (< P30) and adult (> P35) GnRH-GFP transgenic mice expressing green fluorescent protein were used in this study. Acute coronal brain slices containing the preoptic area were prepared, and the identified GnRH neurons were recorded using the gramicidin perforated-patch clamp technique. RESULTS: In young mice, GnRH neurons were excited by bath application of kisspeptin in 36% (13/36) in male, 17% (4/23) in female tested neurons. In adult mice, GnRH neurons were excited in the majority (30/40, 75%) in male, (21/31, 68%) in female neurons tested. However, there was no significant difference between the effects of kisspeptin in male and female mice. In addition, we tested kisspeptin effects in diestrus, proestrus and estrus animals. There were no significant differences of kisspeptin effects over the estrous cycle. Kisspeptin failed to induce excitatory effects on GnRH neurons (6/7, 86%) neurons) by pretreatment of U73122, a protein lipase C (PLC) inhibitor and kisspeptin-induced excitatory effects were decreased by U73122 application (n = 2). CONCLUSION: These results demonstrated that kisspeptin-induced membrane excitability was increased after puberty and this supports a previous suggestion that GPR54 is essential for puberty and subsequent fertility.

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Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty
Young Jun Rhie, Kee Hyoung Lee, So Hee Eun, Byung Min Choi, Hyun Wook Chae, Ah Reum Kwon, Woo Jung Lee, Jung Hyun Kim, Ho-Seong Kim
Journal of Korean Medical Science.2011; 26(7): 927. CrossRef

A Case of Inappropriate Antidiuretic Hormone Syndrome Complicated with Tuberculous Meningitis Refractory to Antituberculosis Drugs.: Ju Hee Oh, Sang Pil Yun, So Young Lee, Yeo Kyung Lee, Young Sun Jung, Soo Kyung Kim, Sung Kwan Hong, Seok Won Park, Yong Wook Cho; J Korean Endocr Soc. 2007;22(3):210-214. Published online June 1, 2007; DOI: https://doi.org/10.3803/jkes.2007.22.3.210

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Abstract PDF: Syndrome of inappropriate antidiuretic hormone is the most common cause of hyponatremia in hospitalized patients. It is defined as retention of water, loss of sodium and inappropriately concentrated urine in euvolemic patients with normal renal and adrenal function. A 26-year old male was admitted due to weight loss and fever that he had experienced for the previous 1 month. The chest X-ray and CT scan of lung showed about 2.5x1.2 cm lymph node enlargement at the left hilum and multiple lymph node enlargements. Thoracoscopic biopsy revealed tuberculosis. During treatment with antituberculosis drugs, the serum sodium was 125 mEq/L, the serum osmolality was 263 mOsm/kg, the urine osmolality was 577 mOsm/kg, and the urine sodium concentration was 177 mEq/L. He was treated by fluid restriction and hypertonic saline infusion, but he did not improve. Brain CT scan showed tuberculous meningitis with hydrocephalus. He fully recovered after undergoing ventriculoperitoneal shunt. We report here on a case of inappropriate antidiuretic hormone syndrome complicated by tuberculous meningitis that was refractory to antituberculosis drugs.

Two Cases of Acromegaly with Empty Sella.: Hyun Sun Cho, Tae Seo Sohn, So Young Lee, Kyoung Hee Kim, Yu Kyung Park, Jung Min Lee, Hyun Shik Son; J Korean Endocr Soc. 2006;21(6):572-576. Published online December 1, 2006; DOI: https://doi.org/10.3803/jkes.2006.21.6.572

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Abstract PDF: An empty sella may develop as a consequence of a primary congenital weakness of the diaphragm for which no secondary cause is evident. A secondary empty sella may develop after infarction of a pituitary adenoma or because of surgical or radiation-induced damage to the sellar diaphragm. Acromegaly is caused by growth hormone (GH) hypersecretion and the resultant elevated levels of circulating insulin like growth factor-1. The underlying abnormality in more than 98% of cases is hypersecretion of GH by a pituitary GH-producing tumor. Necrosis and hemorrhage, which frequently occur in pituitary adenomas, may lead to complete or partial disappearance of the adenoma, and subsequently, to an empty sella. We report two cases of acromegaly with empty sella, and the patients had no symptoms of pituitary apoplexy.

A Case of Early Gastric Cancer Coincidentally Developed in a Patient with Acromegaly.: Kyun Woo Park, So Young Lee, Hye Suk Son, Yi Sun Jang, Hye Soo Kim, Jong Min Lee, Bong Yun Cha, Kwang Woo Lee, Ho Young Son, Sung Koo Kang; J Korean Endocr Soc. 2006;21(2):165-169. Published online April 1, 2006; DOI: https://doi.org/10.3803/jkes.2006.21.2.165

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Abstract PDF: Acromegaly is associated with an increased risk for a variety of cancers such as colon cancer, prostate cancer and breast cancer. However, there have been few reports of gastric cancer developing in an acromegaly patient. A 66-year-old man suffered with diabetes mellitus and hypertension for 15 years, and he visited the endocrinology department due to dizziness. On physical examination, the biochemical studies and the sella MRI, he showed the typical features of acromegaly with pituitary microadenoma. During the cancer screening studies to find the cause of anemia, early gastric cancer was diagnosed by pathologic examination of the tissue biopsies. We described the summary of characteristics of the patient and reviewed literature.

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